RNF19A

Across TCGA pan-cancer cohorts, RNF19A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RNF19A data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RNF19A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF19A expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

UVM, KIRP, and ACC are the cancer types where RNF19A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.272	0.804	<.001	115	view →
KIRP	DFS	Quartile	All	0.551	0.719	<.001	55	view →
ACC	OS	Median	All	0.690	0.888	.001	46	view →
BLCA	OS	Quartile	II,III,IV	0.754	0.610	.007	44	view →
SKCM	DFS	Median	All	0.250	0.152	.001	42	view →
LUSC	DFS	Median	All	0.709	0.784	.008	35	view →
ESCA	DFS	Quartile	III,IV	0.623	0.293	<.001	31	view →
LGG	DFS	Tertile	All	0.619	0.859	<.001	28	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
HNSC	DFS	Quartile	All	0.696	0.528	.001	20	view →
KICH	DFS	Median	II,III,IV	0.715	0.958	.016	19	view →
MESO	DFS	Median	All	0.451	0.277	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RNF19A–UVM (DFS)

Open the UVM breakdown →