RNF19A

Across TCGA cell cohorts, RNF19A mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RNF19A-associated genes across cancer lineages are OR4F4, OR4X2, and OR4B1. Each is linked with RNF19A in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF19A-to-partner and partner-to-RNF19A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by RNF19A-low versus RNF19A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF19A→partner) and Y-score (partner→RNF19A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.016	+3.688	<.001	.002	3	2
LUNG_SCLC	OR4X2 →	+0.045	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4B1 →	+0.044	+5.029	<.001	.006	3	1
SKIN	OR11H1 →	+0.024	+3.297	<.001	.002	3	1
SKIN	CFC1 →	+0.017	+3.217	<.001	.006	3	1
SKIN	GAD2 →	+0.117	+3.514	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR4F4 by RNF19A expression — LARGE_INTESTINE

Explore this box plot interactively →