RNF180

Across TCGA patient cohorts, RNF180 mutation is significantly associated with the RNA expression of many other genes, with 4,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF180-associated genes across cancer lineages are ENO1, TXNL4A, and RPS27L. Each is linked with RNF180 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF180-to-partner and partner-to-RNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENO1 grouped by RNF180-low versus RNF180-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF180→partner) and Y-score (partner→RNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENO1 →	+0.625	+3.016	<.001	<.001	3	3
UCEC	TXNL4A →	+0.424	+2.779	<.001	<.001	3	3
UCEC	RPS27L →	+0.684	+2.758	<.001	<.001	3	3
CESC	RNA5SP188 →	+0.425	+6.164	<.001	<.001	3	2
CESC	MTRES1P1 →	+0.097	+4.539	<.001	.008	3	2
CESC	RN7SL316P →	+0.369	+4.276	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,148 associations by consensus.

ENO1 by RNF180 expression — UCEC

Explore this box plot interactively →