RNF17

Across TCGA patient cohorts, RNF17 mutation is significantly associated with the RNA expression of many other genes, with 5,181 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF17-associated genes across cancer lineages are ZBED4, MTHFD1, and FCER1A. Each is linked with RNF17 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF17-to-partner and partner-to-RNF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBED4 grouped by RNF17-low versus RNF17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF17→partner) and Y-score (partner→RNF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZBED4 →	+0.303	+1.595	.005	.005	3	4
UCEC	MTHFD1 →	+0.441	+2.454	<.001	<.001	3	4
UCEC	FCER1A →	-0.789	-2.523	<.001	<.001	3	4
UCEC	FANCB →	+0.247	+1.584	.007	.002	3	4
COAD	CDCA2 →	+0.700	+3.183	.002	.009	3	4
COAD	WDHD1 →	+0.637	+3.183	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,181 associations by consensus.

ZBED4 by RNF17 expression — UCEC

Explore this box plot interactively →