RNF17

Across TCGA pan-cancer cohorts, RNF17 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RNF17 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher RNF17 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF17 expression acts as an unfavorable survival marker, although some lineages such as LUSC and ACC show a favorable association.

DLBC, LIHC, and LUSC are the cancer types where RNF17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Quartile	II,III,IV	0.257	1.000	.002	93	view →
LIHC	DFS	Quartile	All	0.411	0.615	.001	61	view →
LUSC	DFS	Quartile	III,IV	1.000	0.222	.007	35	view →
READ	DFS	Quartile	IV	0.222	0.692	<.001	29	view →
ACC	OS	Tertile	IV	0.968	0.383	.001	25	view →
COAD	OS	Quartile	All	0.651	0.834	.004	13	view →
KIRC	DFS	Quartile	All	0.529	0.686	.006	11	view →
SKCM	OS	Median	All	0.820	0.749	.012	10	view →
KIRP	OS	Tertile	All	0.455	0.781	.006	10	view →
TGCT	DFS	Tertile	All	0.946	0.724	.004	10	view →
SCLC	DFS	Tertile	IV	0.137	0.489	.036	6	view →
MESO	DFS	Tertile	IV	0.152	0.708	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RNF17–DLBC (OS)

Open the DLBC breakdown →