RNF17

Across TCGA cell cohorts, RNF17 mutation is significantly associated with the RNA expression of many other genes, with 615 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF17-associated genes across cancer lineages are CUEDC2, TST, and ACE. Each is linked with RNF17 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF17-to-partner and partner-to-RNF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC2 grouped by RNF17-low versus RNF17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF17→partner) and Y-score (partner→RNF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.491	+3.523	.003	<.001	3	2
CNS	TST →	+0.632	+3.321	.009	.007	3	2
CNS	ACE →	+0.869	+3.321	<.001	.007	2	3
LARGE_INTESTINE	NAGA →	+0.556	+3.330	.003	.002	3	2
CNS	SHANK3 →	+0.690	+3.321	<.001	.007	3	2
CNS	LINC02881 →	+0.334	+3.459	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 615 associations by consensus.

CUEDC2 by RNF17 expression — LARGE_INTESTINE

Explore this box plot interactively →