RNF169

Across TCGA pan-cancer cohorts, RNF169 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF169 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF169 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF169 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where RNF169 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.833	0.602	.007	9	view →
LUAD	OS	Tertile	II,III,IV	0.946	0.513	.021	8	view →
HNSC	DFS	Median	III,IV	1.000	0.937	.035	2	view →
GBM	DFS	Quartile	All	0.422	0.275	.044	2	view →
CCRCC	OS	Tertile	All	0.912	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF169–LSCC (DFS)

Open the LSCC breakdown →