RNF169

Across TCGA patient cohorts, RNF169 protein abundance is significantly associated with the RNA expression of many other genes, with 5,673 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNF169-associated genes across cancer lineages are THAP12, POLD3, and EMSY. Each is linked with RNF169 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNF169-to-partner and partner-to-RNF169 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF169 versus THAP12 in OV, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF169→partner) and Y-score (partner→RNF169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THAP12 →	+0.766	+0.386	<.001	<.001	3	5
HNSC	POLD3 →	+0.554	+0.290	<.001	<.001	3	5
HNSC	EMSY →	+0.611	+0.299	<.001	<.001	3	4
HNSC	CEP57 →	+0.529	+0.298	<.001	.001	3	4
LSCC	MTBP →	+0.673	+0.299	<.001	.001	3	4
HNSC	COA4 →	+0.579	+0.250	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,673 associations by consensus.

RNF169 vs THAP12 — OV

Explore this scatter interactively →