RNF169

Across TCGA cell cohorts, RNF169 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,355 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF169-associated GO terms across cancer lineages are Protein deubiquitination, Subtelomeric heterochromatin formation, and Centrosome duplication. Each is linked with RNF169 in more than 14 cancer types. Because this analysis shows association rather than direction, both RNF169-to-partner and partner-to-RNF169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein deubiquitination grouped by RNF169-low versus RNF169-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF169→partner) and Y-score (partner→RNF169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein deubiquitination →	+0.072	+1.270	<.001	<.001	3	15
BONE	Subtelomeric heterochromatin formation →	+0.126	+0.865	.002	<.001	3	15
BONE	Centrosome duplication →	+0.115	+0.767	.001	.002	3	14
LUNG_NSCLC_LUSC	Protein modification by small protein removal →	+0.062	+0.977	.002	.001	3	14
LUNG_SCLC	Regulation of sister chromatid cohesion →	+0.108	+0.775	<.001	<.001	3	14
LARGE_INTESTINE	Microtubule organizing center organization →	+0.076	+1.032	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,355 associations by consensus.

Protein deubiquitination by RNF169 expression — LUNG_NSCLC_LUSC

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