RNF169

Across TCGA cell cohorts, RNF169 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RNF169-associated genes across cancer lineages are SPATA31D1, CFHR2, and OR10G7. Each is linked with RNF169 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF169-to-partner and partner-to-RNF169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D1 grouped by RNF169-low versus RNF169-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF169→partner) and Y-score (partner→RNF169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPATA31D1 →	+0.632	+4.643	<.001	.004	3	2
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR10G7 →	+0.009	+4.078	<.001	.009	3	2
LUNG_NSCLC_LUAD	LCE1F →	+0.090	+4.078	<.001	.009	3	2
LUNG_SCLC	F9 →	+0.027	+4.643	<.001	.004	3	1
LUNG_SCLC	OR10G3 →	+0.047	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

SPATA31D1 by RNF169 expression — LUNG_SCLC

Explore this box plot interactively →