RNF167

Across TCGA pan-cancer cohorts, RNF167 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNF167’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RNF167 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RNF167 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and HNSC are the cancer types where RNF167 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF167 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.426	<.001	11	view →
PDAC	All	All	−0.635	<.001	6	view →
HNSC	All	All	+0.189	.002	4	view →
LUAD	Female	All	+0.273	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RNF167–CCRCC

Open the CCRCC breakdown →