RNF166

Across TCGA patient cohorts, RNF166 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF166-associated genes across cancer lineages are RNA5SP442, SERPINE4P, and DMC1. Each is linked with RNF166 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF166-to-partner and partner-to-RNF166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP442 grouped by RNF166-low versus RNF166-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF166→partner) and Y-score (partner→RNF166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP442 →	+0.963	+5.893	<.001	.002	3	1
COAD	SERPINE4P →	+0.692	+5.435	<.001	.005	3	1
UCEC	DMC1 →	+0.564	+3.223	.003	.009	3	1
UCEC	SETDB2 →	+0.460	+3.210	.009	.009	3	1
UCEC	TRIM54 →	+0.836	+3.234	<.001	.009	3	1
UCEC	MIR4672 →	+0.462	+2.626	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

RNA5SP442 by RNF166 expression — COAD

Explore this box plot interactively →