RNF157

Across TCGA cell cohorts, RNF157 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF157-associated genes across cancer lineages are PABPN1L, SH3GL2, and FAM149A. Each is linked with RNF157 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF157-to-partner and partner-to-RNF157 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPN1L grouped by RNF157-low versus RNF157-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF157→partner) and Y-score (partner→RNF157) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PABPN1L →	+0.013	+5.087	<.001	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.411	+3.474	<.001	.003	3	1
LARGE_INTESTINE	FAM149A →	+1.657	+3.067	<.001	.009	3	1
LARGE_INTESTINE	CHRNA2 →	+0.070	+2.938	<.001	.003	3	1
LARGE_INTESTINE	HMX3 →	+0.428	+3.531	.005	.007	3	1
LARGE_INTESTINE	RNF148 →	+0.308	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PABPN1L by RNF157 expression — URINARY_TRACT

Explore this box plot interactively →