RNF157-AS1

Across TCGA pan-cancer cohorts, RNF157-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNF157-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNF157-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF157-AS1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where RNF157-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF157-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.630	<.001	11	view →
KIRC	Male	II,III,IV	−1.535	<.001	11	view →
THCA	Male	III,IV	−2.737	<.001	10	view →
UCEC	All	All	+1.548	.001	6	view →
LUAD	All	All	+0.485	<.001	6	view →
LIHC	All	All	+0.456	<.001	6	view →
COAD	Female	All	+0.316	.001	6	view →
BRCA	All	All	+0.285	<.001	6	view →
LUSC	All	II,III,IV	−0.544	<.001	4	view →
CHOL	Female	All	+3.046	<.001	3	view →
READ	Female	All	+0.298	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNF157-AS1–KICH

Open the KICH breakdown →