RNF152

Across TCGA patient cohorts, RNF152 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF152-associated genes across cancer lineages are p53, mTOR_pS2448, and MIG-6. Each is linked with RNF152 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF152-to-partner and partner-to-RNF152 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by RNF152-low versus RNF152-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF152→partner) and Y-score (partner→RNF152) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p53 →	+0.206	+2.321	.004	.032	3	2
UCEC	mTOR_pS2448 →	-0.259	-3.169	.001	.020	3	2
SKCM	MIG-6 →	+0.154	+1.602	.013	.021	3	1
SKCM	S6_pS240_S244 →	-0.339	-2.321	.037	.033	3	1
SKCM	YB-1_pS102 →	-0.159	-2.459	.017	.018	3	1
SKCM	CD49b →	+0.268	+3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

p53 by RNF152 expression — SKCM

Explore this box plot interactively →