RNF146

Across TCGA pan-cancer cohorts, RNF146 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF146 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF146 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RNF146 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where RNF146 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.830	1.000	<.001	54	view →
HNSC	DFS	Tertile	All	0.887	1.000	.005	15	view →
CCRCC	OS	Tertile	III,IV	0.821	0.432	.006	15	view →
PDAC	OS	Median	II,III,IV	0.376	0.586	.016	11	view →
LUAD	OS	Tertile	II,III,IV	0.894	0.317	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF146–LSCC (OS)

Open the LSCC breakdown →