RNF146

Across TCGA patient cohorts, RNF146 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF146-associated genes across cancer lineages are mTOR_pS2448, Ku80, and Notch1. Each is linked with RNF146 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF146-to-partner and partner-to-RNF146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by RNF146-low versus RNF146-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF146→partner) and Y-score (partner→RNF146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.125	-2.565	.042	.010	3	2
UCEC	Ku80 →	+0.195	+1.820	.045	.016	3	1
UCEC	Notch1 →	+0.154	+1.750	.007	.049	3	1
UCEC	PDCD4 →	-0.609	-2.449	.001	.019	3	1
UCEC	Tuberin →	+0.328	+1.807	.003	.027	3	1
UCEC	4E-BP1_pT37_T46 →	-0.470	-1.807	.002	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

mTOR_pS2448 by RNF146 expression — UCEC

Explore this box plot interactively →