RNF146

Across TCGA cell cohorts, RNF146 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF146-associated genes across cancer lineages are PRR23C, FAM236A, and BPIFA1. Each is linked with RNF146 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF146-to-partner and partner-to-RNF146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23C grouped by RNF146-low versus RNF146-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF146→partner) and Y-score (partner→RNF146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.114	+3.103	.003	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+4.029	.002	.001	3	1
LARGE_INTESTINE	ST6GAL2 →	+0.848	+3.617	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRR23C by RNF146 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →