RNF145

Across TCGA pan-cancer cohorts, RNF145 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF145 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RNF145 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF145 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

LUAD, LIHC, and UCEC are the cancer types where RNF145 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.053	0.835	<.001	44	view →
LIHC	OS	Median	All	0.031	0.775	<.001	26	view →
UCEC	DFS	Median	All	0.931	0.624	.018	20	view →
BLCA	OS	Median	II,III,IV	0.852	0.404	.037	4	view →
SKCM	DFS	Median	II,III,IV	0.907	0.682	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF145–LUAD (OS)

Open the LUAD breakdown →