RNF145

Across TCGA pan-cancer cohorts, RNF145 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNF145’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNF145 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF145 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where RNF145 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF145 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.281	<.001	12	view →
KIRP	All	II,III,IV	+0.930	<.001	11	view →
HNSC	Male	All	+0.798	<.001	10	view →
LUSC	Male	II,III,IV	−1.263	<.001	9	view →
LIHC	All	II,III,IV	+0.874	<.001	8	view →
BRCA	All	III,IV	−1.095	<.001	6	view →
BLCA	All	All	−0.621	.007	6	view →
LUAD	All	II,III,IV	−0.546	<.001	6	view →
CHOL	All	All	+2.330	<.001	5	view →
UCEC	All	III,IV	+0.818	.023	4	view →
STAD	All	All	+0.526	.014	3	view →
ESCA	All	All	+0.937	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNF145–KIRC

Open the KIRC breakdown →