RNF145

Across TCGA pan-cancer cohorts, RNF145 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF145 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RNF145 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF145 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where RNF145 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.386	.002	50	view →
LUAD	DFS	Median	III,IV	0.526	0.947	.006	14	view →
HNSC	DFS	Quartile	All	1.000	0.888	.021	9	view →
GBM	OS	Median	All	0.650	0.363	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF145–UCEC (DFS)

Open the UCEC breakdown →