RNF145

Across TCGA patient cohorts, RNF145 mutation is significantly associated with the RNA expression of many other genes, with 4,641 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF145-associated genes across cancer lineages are RNU6-618P, RNA5SP420, and MIR6765. Each is linked with RNF145 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF145-to-partner and partner-to-RNF145 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-618P grouped by RNF145-low versus RNF145-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF145→partner) and Y-score (partner→RNF145) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-618P →	+0.372	+2.993	<.001	.009	3	3
UCEC	RNA5SP420 →	+0.420	+1.534	<.001	.004	3	3
SKCM	MIR6765 →	+0.166	+4.678	<.001	.003	3	3
LGG	CST8 →	+0.043	+5.679	<.001	.003	3	2
SKCM	MIR6871 →	+0.666	+3.032	<.001	.002	3	2
BRCA	CDRT15P7 →	+0.094	+5.122	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,641 associations by consensus.

RNU6-618P by RNF145 expression — LUSC

Explore this box plot interactively →