RNF145

Across TCGA patient cohorts, RNF145 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF145-associated genes across cancer lineages are p62 Lck ligand, STAT3_pY705, and ASNS. Each is linked with RNF145 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF145-to-partner and partner-to-RNF145 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RNF145-low versus RNF145-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF145→partner) and Y-score (partner→RNF145) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.299	+1.817	.005	.015	3	2
UCEC	STAT3_pY705 →	-0.392	-1.726	<.001	.006	3	2
UCEC	ASNS →	+0.295	+1.765	.013	.013	3	2
UCEC	4E-BP1 →	+0.283	+2.444	.001	.001	3	2
UCEC	eEF2 →	+0.333	+2.807	.004	.002	3	1
UCEC	EGFR_pY1068 →	-0.301	-3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p62 Lck ligand by RNF145 expression — UCEC

Explore this box plot interactively →