RNF144A

Across TCGA pan-cancer cohorts, RNF144A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF144A data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RNF144A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF144A expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

LUSC, COAD, and SKCM are the cancer types where RNF144A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.182	0.748	<.001	25	view →
COAD	OS	Median	All	0.001	0.871	<.001	14	view →
SKCM	OS	Median	All	0.179	0.781	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	DFS	Median	III,IV	0.849	0.324	.036	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF144A–LUSC (OS)

Open the LUSC breakdown →