RNF139

Across TCGA patient cohorts, RNF139 mutation is significantly associated with the RNA expression of many other genes, with 2,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF139-associated genes across cancer lineages are RNU6-144P, RPS15AP3, and RNU6ATAC25P. Each is linked with RNF139 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF139-to-partner and partner-to-RNF139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-144P grouped by RNF139-low versus RNF139-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF139→partner) and Y-score (partner→RNF139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-144P →	+0.303	+4.899	<.001	.005	3	3
COAD	RPS15AP3 →	+0.457	+5.003	<.001	.004	3	2
COAD	RNU6ATAC25P →	+0.715	+5.917	<.001	.001	3	2
COAD	VN1R66P →	+0.056	+5.917	<.001	.001	3	2
COAD	UBFD1P1 →	+0.089	+5.721	.009	.001	3	2
CESC	CPLX3 →	+0.026	+6.342	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,263 associations by consensus.

RNU6-144P by RNF139 expression — BLCA

Explore this box plot interactively →