RNF139

Across TCGA pan-cancer cohorts, RNF139 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RNF139 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RNF139 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF139 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

UVM, CESC, and LGG are the cancer types where RNF139 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.408	0.799	<.001	113	view →
CESC	DFS	Quartile	III,IV	0.314	0.930	.004	62	view →
LGG	DFS	Tertile	All	0.804	0.641	<.001	31	view →
SCLC	DFS	Quartile	All	0.320	0.644	.009	29	view →
KIRC	DFS	Quartile	All	0.874	0.662	.001	26	view →
KIRP	OS	Median	III,IV	0.153	0.809	.002	23	view →
LIHC	DFS	Tertile	All	0.468	0.626	.002	22	view →
PAAD	OS	Median	All	0.275	0.497	.008	20	view →
HNSC	OS	Tertile	III,IV	0.584	0.733	.021	17	view →
BRCA	DFS	Quartile	III,IV	0.937	0.783	.009	12	view →
SKCM	DFS	Tertile	IV	0.059	0.675	.004	11	view →
READ	OS	Median	IV	0.512	0.913	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RNF139–UVM (DFS)

Open the UVM breakdown →