RNF139

Across TCGA cell cohorts, RNF139 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,010 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF139-associated GO terms across cancer lineages are Negative regulation of protein localization to centrosome, Response to biphenyl, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with RNF139 in more than 10 cancer types. Because this analysis shows association rather than direction, both RNF139-to-partner and partner-to-RNF139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to centrosome grouped by RNF139-low versus RNF139-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF139→partner) and Y-score (partner→RNF139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of protein localization to centrosome →	+0.115	+0.709	<.001	<.001	3	11
BREAST	Response to biphenyl →	+0.115	+1.292	<.001	<.001	3	9
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.088	+0.613	<.001	<.001	3	8
BLOOD_Leukemia	Vesicle tethering →	+0.066	+0.685	<.001	<.001	3	8
LIVER	Blastocyst growth →	+0.159	+0.794	.003	.001	2	9
BLOOD_Leukemia	Protein catabolic process at synapse →	+0.139	+0.596	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,010 associations by consensus.

Negative regulation of protein localization to centrosome by RNF139 expression — SKIN

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