RNF139

Across TCGA cell cohorts, RNF139 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF139-associated genes across cancer lineages are FAM240B, C18orf63, and OR10W1. Each is linked with RNF139 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF139-to-partner and partner-to-RNF139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM240B grouped by RNF139-low versus RNF139-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF139→partner) and Y-score (partner→RNF139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM240B →	+0.029	+5.969	<.001	.001	3	1
BLOOD_Lymphoma	C18orf63 →	+0.019	+4.867	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	RTCA →	+0.507	+3.215	.009	.009	2	1
LARGE_INTESTINE	CHAF1A →	+0.810	+3.215	.005	.009	2	1
LARGE_INTESTINE	SF3A3 →	+0.671	+3.064	.002	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM240B by RNF139 expression — BLOOD_Leukemia

Explore this box plot interactively →