RNF139-AS1

Across TCGA pan-cancer cohorts, RNF139-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNF139-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF139-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF139-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where RNF139-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF139-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.290	<.001	12	view →
BLCA	Male	All	+0.698	<.001	10	view →
COAD	Female	II,III,IV	+0.481	<.001	10	view →
LIHC	Female	II,III,IV	+0.250	<.001	8	view →
LUSC	All	II,III,IV	+0.357	<.001	7	view →
BRCA	All	II,III,IV	+0.520	<.001	6	view →
STAD	All	II,III,IV	+0.437	<.001	6	view →
CHOL	Female	All	+1.350	<.001	5	view →
READ	All	All	+0.617	<.001	5	view →
LUAD	All	All	+0.313	<.001	3	view →
ESCA	All	All	+0.571	.029	2	view →
KICH	Female	All	−0.322	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNF139-AS1–HNSC

Open the HNSC breakdown →