RNF138

Across TCGA patient cohorts, RNF138 protein abundance is significantly associated with the RNA expression of many other genes, with 9,410 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNF138-associated genes across cancer lineages are CCNF, POLE, and AFG3L2. Each is linked with RNF138 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF138-to-partner and partner-to-RNF138 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF138 versus CCNF in UCEC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF138→partner) and Y-score (partner→RNF138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNF →	+0.710	+0.233	<.001	<.001	3	4
UCEC	POLE →	+0.670	+0.234	.003	.003	3	4
CCRCC	AFG3L2 →	+0.557	+0.605	.001	.001	3	4
UCEC	SNRPD1 →	+0.722	+0.293	<.001	.003	3	4
LSCC	GINS1 →	+1.065	+0.501	<.001	<.001	3	4
LSCC	MCM4 →	+0.692	+0.304	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,410 associations by consensus.

RNF138 vs CCNF — UCEC

Explore this scatter interactively →