RNF138

Across TCGA pan-cancer cohorts, RNF138 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RNF138 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RNF138 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF138 expression acts as an unfavorable survival marker, although some lineages such as BRCA and COAD show a favorable association.

ACC, MESO, and BRCA are the cancer types where RNF138 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.415	0.732	<.001	92	view →
MESO	OS	Quartile	All	0.396	0.674	.002	72	view →
BRCA	DFS	Tertile	All	0.969	0.919	.001	38	view →
COAD	DFS	Median	II,III,IV	0.531	0.361	.006	38	view →
OV	DFS	Quartile	II,III,IV	0.615	0.496	.015	36	view →
READ	OS	Tertile	II,III,IV	0.877	0.320	.001	26	view →
KIRC	DFS	Tertile	All	0.877	0.703	.002	26	view →
LGG	OS	Quartile	All	0.679	0.880	<.001	23	view →
THYM	OS	Tertile	All	1.000	0.755	.009	14	view →
UVM	DFS	Tertile	III,IV	0.272	0.860	.004	13	view →
LUSC	OS	Quartile	All	0.834	0.731	.003	13	view →
KIRP	DFS	Tertile	III,IV	0.176	0.629	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RNF138–ACC (DFS)

Open the ACC breakdown →