RNF138

Across TCGA patient cohorts, RNF138 mutation is significantly associated with the RNA expression of many other genes, with 2,603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF138-associated genes across cancer lineages are RN7SKP181, MIR1269A, and RNU6-1326P. Each is linked with RNF138 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF138-to-partner and partner-to-RNF138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by RNF138-low versus RNF138-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF138→partner) and Y-score (partner→RNF138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.097	+2.207	<.001	.006	3	3
COAD	MIR1269A →	+0.373	+5.251	<.001	.003	3	2
STAD	RNU6-1326P →	+0.351	+5.928	<.001	.002	3	2
STAD	MIR548M →	+0.661	+5.463	<.001	.005	3	2
STAD	TSPY20P →	+0.128	+5.928	.008	.002	3	2
UCEC	RNU6-871P →	+0.278	+3.132	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,603 associations by consensus.

RN7SKP181 by RNF138 expression — UCEC

Explore this box plot interactively →