RNF138

Across TCGA patient cohorts, RNF138 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF138-associated genes across cancer lineages are EGFR_pY1068, ERK2, and ACC_pS79. Each is linked with RNF138 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF138-to-partner and partner-to-RNF138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RNF138-low versus RNF138-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF138→partner) and Y-score (partner→RNF138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.312	-3.584	.001	.002	3	1
UCEC	ERK2 →	+0.230	+2.000	.002	.010	3	1
UCEC	ACC_pS79 →	+0.314	+2.000	.021	.010	3	1
UCEC	FOXO3a →	-0.115	-2.555	.003	.011	3	1
UCEC	ACC1 →	+0.369	+2.183	.009	.033	3	1
UCEC	Heregulin →	-0.118	-1.584	.015	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by RNF138 expression — UCEC

Explore this box plot interactively →