RNF138

Across TCGA cell cohorts, RNF138 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,683 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF138-associated GO terms across cancer lineages are DNA strand elongation, Regulation of microtubule-based process, and Regulation of sister chromatid segregation. Each is linked with RNF138 in more than 13 cancer types. Because this analysis shows association rather than direction, both RNF138-to-partner and partner-to-RNF138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by RNF138-low versus RNF138-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF138→partner) and Y-score (partner→RNF138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation →	+0.112	+0.649	.005	<.001	3	14
LUNG_SCLC	Regulation of microtubule-based process →	+0.068	+0.820	<.001	<.001	3	14
KIDNEY	Regulation of sister chromatid segregation →	+0.133	+1.133	<.001	<.001	3	14
PANCREAS	Defense response to bacterium →	-0.109	-1.160	<.001	<.001	3	14
OVARY	Spindle assembly →	+0.078	+1.279	<.001	<.001	3	14
KIDNEY	Establishment of meiotic spindle orientation →	+0.163	+0.951	.002	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,683 associations by consensus.

DNA strand elongation by RNF138 expression — BONE

Explore this box plot interactively →