RNF130

Across TCGA patient cohorts, RNF130 mutation is significantly associated with the RNA expression of many other genes, with 1,073 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF130-associated genes across cancer lineages are OR9Q2, ZNF725P, and SCP2D1. Each is linked with RNF130 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF130-to-partner and partner-to-RNF130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9Q2 grouped by RNF130-low versus RNF130-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF130→partner) and Y-score (partner→RNF130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR9Q2 →	+0.057	+5.136	<.001	.002	3	2
COAD	ZNF725P →	+0.104	+3.831	.003	.007	3	2
HNSC	SCP2D1 →	+0.067	+5.221	<.001	.003	3	2
HNSC	SNORD66 →	+0.767	+4.565	<.001	.004	3	2
UCEC	RNU6-7 →	+0.368	+2.076	<.001	.001	3	2
UCEC	RNA5SP77 →	+0.588	+1.838	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,073 associations by consensus.

OR9Q2 by RNF130 expression — COAD

Explore this box plot interactively →