RNF128

Across TCGA patient cohorts, RNF128 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF128-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and GAPDH. Each is linked with RNF128 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF128-to-partner and partner-to-RNF128 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RNF128-low versus RNF128-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF128→partner) and Y-score (partner→RNF128) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.873	+2.000	<.001	<.001	3	3
UCEC	ERK2 →	+0.219	+1.716	<.001	.003	3	2
UCEC	GAPDH →	+0.455	+1.584	.008	.017	3	2
UCEC	p62 Lck ligand →	+0.310	+2.009	.003	.005	3	2
UCEC	PCNA →	+0.256	+2.321	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.197	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by RNF128 expression — UCEC

Explore this box plot interactively →