RNF128

Across TCGA pan-cancer cohorts, RNF128 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNF128’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNF128 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF128 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and LUAD are the cancer types where RNF128 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF128 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−4.893	<.001	10	view →
LUSC	Female	II,III,IV	−2.692	<.001	7	view →
LUAD	Female	III,IV	−2.306	<.001	7	view →
KIRC	Male	II,III,IV	+0.649	<.001	7	view →
KIRP	Male	II,III,IV	+1.332	<.001	6	view →
BRCA	Female	All	−0.939	<.001	6	view →
BLCA	Male	IV	+4.692	.026	4	view →
STAD	Male	All	+1.911	<.001	4	view →
COAD	All	All	+0.570	.001	4	view →
READ	Female	All	+1.334	.002	2	view →
PRAD	All	All	−1.071	<.001	2	view →
CHOL	All	All	−0.914	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNF128–KICH

Open the KICH breakdown →