RNF126

Across TCGA pan-cancer cohorts, RNF126 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF126 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RNF126 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF126 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where RNF126 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.823	0.595	.003	29	view →
UCEC	DFS	Tertile	All	0.969	0.754	.009	14	view →
CCRCC	DFS	Tertile	All	0.664	0.912	.004	9	view →
HNSC	DFS	Median	All	0.727	0.561	.036	4	view →
LUAD	OS	Quartile	All	0.439	0.856	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF126–PDAC (DFS)

Open the PDAC breakdown →