RNF126

Across TCGA pan-cancer cohorts, RNF126 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNF126’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNF126 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF126 is over-expressed in tumor.

KIRC, COAD, and HNSC are the cancer types where RNF126 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF126 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.871	<.001	12	view →
COAD	Female	All	+1.101	<.001	11	view →
HNSC	Male	III,IV	+0.883	<.001	10	view →
LIHC	Female	All	+0.859	<.001	9	view →
STAD	Male	II,III,IV	+0.796	<.001	9	view →
KIRP	All	III,IV	+0.576	<.001	9	view →
LUSC	Male	II,III,IV	+0.954	<.001	8	view →
BLCA	All	III,IV	+0.684	<.001	8	view →
UCEC	All	III,IV	+0.584	<.001	6	view →
CHOL	Male	All	+1.235	<.001	4	view →
ESCA	All	All	+0.986	.009	2	view →
READ	All	All	+0.768	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNF126–KIRC

Open the KIRC breakdown →