RNF126

Across TCGA patient cohorts, RNF126 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF126-associated genes across cancer lineages are ERK2, S6_pS240_S244, and Caspase-7-cleavedD198. Each is linked with RNF126 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF126-to-partner and partner-to-RNF126 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RNF126-low versus RNF126-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF126→partner) and Y-score (partner→RNF126) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.239	+2.321	.013	.035	2	2
UCEC	S6_pS240_S244 →	+0.557	+2.321	.006	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+1.167	+2.189	<.001	.034	3	1
UCEC	Cyclin-B1 →	+0.642	+3.459	.022	.005	3	1
UCEC	Annexin-1 →	+0.799	+2.321	.002	.035	1	2
UCEC	Chk2_pT68 →	-0.195	-3.160	.037	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ERK2 by RNF126 expression — UCEC

Explore this box plot interactively →