RNF122

Across TCGA pan-cancer cohorts, RNF122 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF122 data layer compared with 16 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF122 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF122 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where RNF122 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.223	0.854	.024	4	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.371	.040	4	view →
LUAD	OS	Tertile	III,IV	1.000	0.363	.040	3	view →
GBM	DFS	Median	All	0.310	0.472	.038	2	view →
HNSC	DFS	Median	III,IV	0.401	0.679	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF122–LSCC (DFS)

Open the LSCC breakdown →