RNF122

Across TCGA patient cohorts, RNF122 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF122-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and HER3_pY1289. Each is linked with RNF122 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF122-to-partner and partner-to-RNF122 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RNF122-low versus RNF122-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF122→partner) and Y-score (partner→RNF122) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.126	-3.000	.044	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.143	-3.321	.029	.010	3	1
UCEC	HER3_pY1289 →	+0.101	+3.019	.025	.019	3	1
UCEC	AMPK_pT172 →	+0.650	+3.335	.002	.005	3	1
UCEC	eIF4E →	+0.274	+3.169	.013	.019	2	1
UCEC	4E-BP1 →	+0.287	+2.837	.043	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

A-Raf_pS299 by RNF122 expression — UCEC

Explore this box plot interactively →