RNF115

Across TCGA pan-cancer cohorts, RNF115 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RNF115 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNF115 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF115 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where RNF115 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.890	0.992	<.001	120	view →
CCRCC	DFS	Quartile	All	0.251	1.000	.003	41	view →
PDAC	OS	Quartile	All	0.499	0.863	.021	8	view →
LSCC	DFS	Median	II,III,IV	0.676	0.871	.009	7	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →
UCEC	DFS	Median	All	1.000	0.930	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNF115–HNSC (DFS)

Open the HNSC breakdown →