RNF115

Across TCGA pan-cancer cohorts, RNF115 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNF115’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNF115 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF115 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, LIHC, and LUAD are the cancer types where RNF115 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF115 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.113	<.001	11	view →
LIHC	Male	II,III,IV	+0.977	<.001	9	view →
LUAD	Male	II,III,IV	+0.463	<.001	9	view →
KIRC	Female	All	+0.379	<.001	9	view →
HNSC	Female	III,IV	+0.713	.007	6	view →
COAD	All	II,III,IV	+0.380	<.001	6	view →
BRCA	All	II,III,IV	+0.359	<.001	6	view →
CHOL	Male	All	+1.750	<.001	3	view →
READ	All	II,III,IV	+0.632	.012	3	view →
BLCA	Male	IV	−0.967	.030	2	view →
LUSC	All	III,IV	−0.388	.027	2	view →
UCEC	All	All	−0.383	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RNF115–KICH

Open the KICH breakdown →