RNF114

Across TCGA patient cohorts, RNF114 mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF114-associated genes across cancer lineages are RNU6-13P, CCL27, and RNU6-918P. Each is linked with RNF114 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF114-to-partner and partner-to-RNF114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by RNF114-low versus RNF114-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF114→partner) and Y-score (partner→RNF114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-13P →	+0.278	+4.594	<.001	.008	3	2
SKCM	CCL27 →	+0.086	+4.680	<.001	.007	3	2
UCEC	RNU6-918P →	+0.338	+2.835	<.001	.003	3	2
UCEC	ZDHHC20P3 →	+0.334	+2.315	<.001	.001	3	2
SKCM	OR4M1 →	+0.051	+4.513	<.001	.009	3	1
SKCM	KCNK18 →	+0.051	+6.098	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

RNU6-13P by RNF114 expression — SKCM

Explore this box plot interactively →