RNF112

Across TCGA patient cohorts, RNF112 mutation is significantly associated with the RNA expression of many other genes, with 2,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF112-associated genes across cancer lineages are PLEKHH3, RHBDD3, and ITPK1. Each is linked with RNF112 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF112-to-partner and partner-to-RNF112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHH3 grouped by RNF112-low versus RNF112-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF112→partner) and Y-score (partner→RNF112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLEKHH3 →	+0.707	+3.010	<.001	<.001	3	3
UCEC	RHBDD3 →	+0.535	+3.000	.001	.001	3	2
SKCM	ITPK1 →	+0.577	+2.594	.003	.006	3	2
SKCM	EMD →	+0.378	+3.681	<.001	.001	3	2
SKCM	UQCRC1 →	+0.490	+2.597	<.001	.005	3	2
SKCM	PPP1R37 →	+0.521	+2.472	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,148 associations by consensus.

PLEKHH3 by RNF112 expression — UCEC

Explore this box plot interactively →