RNF112

Across TCGA pan-cancer cohorts, RNF112 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RNF112 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RNF112 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF112 expression acts as an unfavorable survival marker, although some lineages such as LGG and UVM show a favorable association.

KIRP, COAD, and ACC are the cancer types where RNF112 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.525	0.846	<.001	144	view →
COAD	DFS	Tertile	All	0.550	0.760	<.001	72	view →
ACC	DFS	Median	III,IV	0.275	0.734	<.001	54	view →
LGG	OS	Median	All	0.526	0.384	<.001	41	view →
UVM	OS	Median	III,IV	0.857	0.505	.010	30	view →
SKCM	DFS	Quartile	II,III,IV	0.873	0.562	.001	30	view →
LAML	DFS	Tertile	All	0.144	0.540	.002	28	view →
MESO	DFS	Tertile	All	0.299	0.527	.002	26	view →
LUSC	DFS	Quartile	All	0.703	0.905	.008	21	view →
BRCA	DFS	Quartile	IV	0.296	0.740	.012	17	view →
SARC	OS	Quartile	All	0.857	0.593	.003	15	view →
THYM	DFS	Quartile	II,III,IV	0.737	1.000	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RNF112–KIRP (OS)

Open the KIRP breakdown →