RNF111

Across TCGA patient cohorts, RNF111 mutation is significantly associated with the RNA expression of many other genes, with 5,680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF111-associated genes across cancer lineages are PRAMEF8, RNA5SP436, and RNA5SP422. Each is linked with RNF111 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF111-to-partner and partner-to-RNF111 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF8 grouped by RNF111-low versus RNF111-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF111→partner) and Y-score (partner→RNF111) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PRAMEF8 →	+0.087	+3.517	<.001	.006	3	3
LUSC	RNA5SP436 →	+0.643	+4.780	<.001	.003	3	3
LUSC	RNA5SP422 →	+0.629	+4.412	<.001	.006	3	3
BLCA	RNU6-380P →	+0.208	+5.051	<.001	.001	3	3
BLCA	C4BPAP1 →	+0.216	+3.120	<.001	.001	3	3
UCEC	RNA5SP369 →	+0.224	+1.561	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,680 associations by consensus.

PRAMEF8 by RNF111 expression — LUSC

Explore this box plot interactively →