RNF103

Across TCGA patient cohorts, RNF103 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF103-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Annexin-1. Each is linked with RNF103 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF103-to-partner and partner-to-RNF103 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RNF103-low versus RNF103-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF103→partner) and Y-score (partner→RNF103) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.259	-2.321	.001	.005	3	2
UCEC	eIF4E →	+0.167	+3.472	.016	.002	3	2
UCEC	Annexin-1 →	+0.658	+3.019	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.222	+2.145	.012	.009	3	2
UCEC	C-Raf →	+0.145	+2.321	.002	<.001	3	2
UCEC	EGFR →	-0.181	-2.558	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

EGFR_pY1068 by RNF103 expression — UCEC

Explore this box plot interactively →