RNF103

Across TCGA cell cohorts, RNF103 mutation is significantly associated with the mutation status of many other genes, with 1,837 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF103-associated genes across cancer lineages are HIPK1, SOBP, and CLTC. Each is linked with RNF103 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNF103-to-partner and partner-to-RNF103 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIPK1 grouped by RNF103-low versus RNF103-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF103→partner) and Y-score (partner→RNF103) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HIPK1 →	+4.187	+5.000	.008	.008	1	5
LARGE_INTESTINE	SOBP →	+2.215	+4.169	<.001	<.001	1	5
BLOOD_Leukemia	CLTC →	+3.108	+3.108	.008	.008	1	4
SOFT_TISSUE	ANKRD52 →	+5.502	+5.502	.003	.003	1	4
CNS	TCF20 →	+5.000	+4.044	.008	.008	1	4
CNS	DAB1 →	+5.000	+4.044	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,837 associations by consensus.

HIPK1 by RNF103 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →